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Delpire, E, Days, E, Lewis, LM, Mi, D, Kim, K, Lindsley, CW, Weaver, CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A, , , 2009. PMCID:2654392 Geng, Y, Hoke, A, Delpire, E. The STE20 kinases SPAK and OSR1 regulate NKCC1 function in sensory neurons. J Biol Chem, , , 2009. PMCID:2682850 Delpire, E, Gagnon, KB. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J, 409(2), 321-31, 2008. Garbarini, N, Delpire, E. The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2. Cell Physiol Biochem, 22(1-4), 31-44, 2008. PMCID:2535904 Zhu, L, Polley, N, Mathews, GC, Delpire, E. NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus. Epilepsy Res, 79(2-3), 201-12, 2008. PMCID:2394664 Byun, N, Delpire, E. Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice. Neurobiol Dis, 28(1), 39-51, 2007. PMCID:2242858 Delpire, E, Gagnon, KB. Genome-wide analysis of SPAK/OSR1 binding motifs. Physiol Genomics, 28(2), 223-31, 2007. Gagnon, KB, England, R, Delpire, E. A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter. Cell Physiol Biochem, 20(1-4), 131-42, 2007. Gagnon, KB, England, R, Diehl, L, Delpire, E. Apoptosis associated tyrosine kinase scaffolding of protein phosphatase 1 and
SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation. Am J Physiol Cell Physiol, , , 2007. Garzón-Muvdi, T, Pacheco-Alvarez, D, Gagnon, KB, Vázquez, N, Ponce-Coria, J, Moreno, E, Delpire, E, Gamba, G. WNK4 kinase is a negative regulator of K+-Cl- cotransporters. Am J Physiol Renal Physiol, 292(4), F1197-207, 2007. Pieraut, S, Laurent-Matha, V, Sar, C, Hubert, T, Méchaly, I, Hilaire, C, Mersel, M, Delpire, E, Valmier, J, Scamps, F. NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons. J Neurosci, 27(25), 6751-9, 2007. Uvarov, P, Ludwig, A, Markkanen, M, Pruunsild, P, Kaila, K, Delpire, E, Timmusk, T, Rivera, C, Airaksinen, MS. A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem, 282(42), 30570-6, 2007. Zhang, LL, Delpire, E, Vardi, N. NKCC1 does not accumulate chloride in developing retinal neurons. J Neurophysiol, 98(1), 266-77, 2007. Blaesse, P, Guillemin, I, Schindler, J, Schweizer, M, Delpire, E, Khiroug, L, Friauf, E, Nothwang, HG. Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J Neurosci, 26(41), 10407-19, 2006. Delpire, E, Gagnon, KB. SPAK and OSR1, key kinases involved in the regulation of chloride transport. Acta Physiol (Oxf), 187(1-2), 103-13, 2006. Gagnon, Kenneth B E, England, Roger, Delpire, Eric. Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction
of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. Am J Physiol Cell Physiol, 290(1), C134-42, 2006. Gagnon, Kenneth B E, England, Roger, Delpire, Eric. Characterization of SPAK and OSR1, Regulatory Kinases of the Na-K-2Cl Cotransporter. Mol Cell Biol, 26(2), 689-98, 2006. PMCID:1346913 Wouters, M, De Laet, A, Donck, LV, Delpire, E, van Bogaert, PP, Timmermans, JP, de Kerchove d''Exaerde, A, Smans, K, Vanderwinden, JM. Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker. Am J Physiol Gastrointest Liver Physiol, 290(6), G1219-27, 2006. Dzhala, VI, Talos, DM, Sdrulla, DA, Brumback, AC, Mathews, GC, Benke, TA, Delpire, E, Jensen, FE, Staley, KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med, 11(11), 1205-13, 2005. Mercado, A, Vázquez, N, Song, L, Cortés, R, Enck, AH, Welch, R, Delpire, E, Gamba, G, Mount, DB. NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. Am J Physiol Renal Physiol, 289(6), F1246-61, 2005. Zhu, Lei, Lovinger, David, Delpire, Eric. Cortical neurons lacking KCC2 expression show impaired regulation of intracellular
chloride. J Neurophysiol, 93(3), 1557-68, 2005. Adragna, NC, Chen, Y, Delpire, E, Lauf, PK, Morris, M. Hypertension in K-Cl cotransporter-3 knockout mice. Adv Exp Med Biol, 559, 379-85, 2004. Delpire, E, Piechotta, K. STE20 kinases and cation-chloride cotransporters. Adv Exp Med Biol, 559, 43-53, 2004. Karadsheh, M F, Byun, N, Mount, D B, Delpire, E. Localization of the KCC4 potassium-chloride cotransporter in the nervous system. Neuroscience, 123(2), 381-91, 2004. Laird, JM, GarcÃa-Nicas, E, Delpire, EJ, Cervero, F. Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia. Neurosci Lett, 361(1-3), 200-3, 2004. Laird, JMA, E. Garcia-Nicas, E. Delpire. Presynaptic inhimbition and spinal pain processing: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia. Neurosci. Lett., 361, 200-203, 2004. Piechotta, Kerstin, Garbarini, Nicole, England, Roger, Delpire, Eric. Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. J Biol Chem, 278(52), 52848-56, 2003. Thomson, R Brent, Mentone, SueAnn, Kim, Robert, Earle, Karen, Delpire, Eric, Somlo, Stefan, Aronson, Peter S. Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. Am J Physiol Renal Physiol, 285(5), F870-80, 2003. Delpire E. and D.B. Mount. Human and mouse phenotypes associated with defects in cation-chloride cotransporters. Ann. Rev. Physiol., 64, 803-843, 2002. Delpire, Eric, Mount, David B. Human and murine phenotypes associated with defects in cation-chloride cotransport. Annu Rev Physiol, 64, 803-43, 2002. Howard, Heidi C, Mount, David B, Rochefort, Daniel, Byun, Nellie, Dupré, Nicolas, Lu, Jianming, Fan, Xuemo, Song, Luyan, Rivière, Jean-Baptiste, Prévost, Claude, Horst, Jürgen, Simonati, Alessandro, Lemcke, Beate, Welch, Rick, England, Roger, Zhan, Frank Q, Mercado, Adriana, Siesser, William B, George, Alfred L, McDonald, Michael P, Bouchard, Jean-Pierre, Mathieu, Jean, Delpire, Eric, Rouleau, Guy A. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet, 32(3), 384-92, 2002. Piechotta, K., Lu, J., and E. Delpire. Cation-chloride cotransporters interact with the stress-related kinases SPAK and OSR1 . J. Biol. Chem., 277(52), 50812-50819, 2002. Piechotta, Kerstin, Lu, Jianming, Delpire, Eric. Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem, 277(52), 50812-9, 2002. Woo N-S, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E. Hyper-excitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus, 12, 458-468, 2002. Woo, Nam-Sik, Lu, Jianming, England, Roger, McClellan, Robert, Dufour, Samuel, Mount, David B, Deutch, Ariel Y, Lovinger, David M, Delpire, Eric. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus, 12(2), 258-68, 2002. Karadsheh MF and Delpire E. A neuronal restrictive silencing element is found in the KCC2 gene: Molecular Basis for KCC2 specific expression in neurons. J. Neurophysiol., 85, 995-997, 2001. Karadsheh, M F, Delpire, E. Neuronal restrictive silencing element is found in the KCC2 gene: molecular basis for KCC2-specific expression in neurons. J Neurophysiol, 85(2), 995-7, 2001. Lauf, P K, Zhang, J, Delpire, E, Fyffe, R E, Mount, D B, Adragna, N C. K-Cl co-transport: immunocytochemical and functional evidence for more than one KCC isoform in high K and low K sheep erythrocytes. Comp Biochem Physiol A Mol Integr Physiol, 130(3), 499-509, 2001. Lauf, P K, Zhang, J, Gagnon, K B, Delpire, E, Fyffe, R E, Adragna, N C. K-Cl cotransport: immunohistochemical and ion flux studies in human embryonic kidney (HEK293) cells transfected with full-length and C-terminal-domain-truncated KCC1 cDNAs. Cell Physiol Biochem, 11(3), 143-60, 2001. Pearson MM, Lu J, Mount DB and Delpire E. Cellular localization of KCC3 in the central and peripheral nervous systems: expression in choroid plexus, large neurons, and white matter tracts. Neuroscience, 103(2), 483-493, 2001. Pearson, M M, Lu, J, Mount, D B, Delpire, E. Localization of the K(+)-Cl(-) cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts. Neuroscience, 103(2), 481-91, 2001. Delpire E. Cation-chloride cotransporters in neuronal communication. NIPS, 15, 309-312, 2000. Delpire, E.. Cation-Chloride Cotransporters in Neuronal Communication. News Physiol Sci, 15, 309-312, 2000. Strange K, Singer TD, Morrison R and Delpire E. Dependence of KCC2 K-Cl cotransporter activity on a
conserved carboxy terminus tyrosine residue. Am J Physiol Cell Physiol, 279(3), C860-867, 2000. Strange, K, Singer, T D, Morrison, R, Delpire, E. Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue. Am J Physiol Cell Physiol, 279(3), C860-7, 2000. Sung, K W, Kirby, M, McDonald, M P, Lovinger, D M, Delpire, E. Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice. J Neurosci, 20(20), 7531-8, 2000. iSung K-W, Kirby M, McDonald MP, Lovinger DM and Delpire E. Abnormal GABAA-receptor mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice. J. Neurosci., 20(20), 7531-7538, 2000. Delpire E, Lu J, England R, Dull C and Thorne T. Deafness
and imbalance associated with inactivation of the secretory
Na-K-2Cl cotransporter. Nature Genet, 22, 192-195, 1999. Delpire, E, Lu, J, England, R, Dull, C, Thorne, T. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nat Genet, 22(2), 192-5, 1999. Klingensmith, M E, Neville, L J, Delpire, E, Wolfe, M M, Soybel, D I. Gastrin-mediated effects of omeprazole on rat colon mucosa. Surgery, 126(2), 272-8, 1999. Lu J, Karadsheh M and Delpire E. Developmental regulation
of the neuronal-specific isoform of the K-Cl cotransporter,
KCC2, in postnatal rat brains. J Neurobiol, 39, 558-568, 1999. Lu, J, Karadsheh, M, Delpire, E. Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains. J Neurobiol, 39(4), 558-68, 1999. Mount, D B, Mercado, A, Song, L, Xu, J, George, A L, Delpire, E, Gamba, G. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem, 274(23), 16355-62, 1999. Hallonquist, H, Cima, R R, Klingensmith, M E, Purdy, M J, Delpire, E, Zinner, M J, Soybel, D I. Selective increase in gastric mucosal mRNA encoding basolateral Na-K-2C1 cotransporter following ileostomy in the rat. J Gastrointest Surg, 2(3), 238-43, 1998. Mount, D B, Delpire, E, Gamba, G, Hall, A E, Poch, E, Hoover, R S, Hebert, S C. The electroneutral cation-chloride cotransporters. J Exp Biol, 201 ( Pt 14), 2091-102, 1998. Wu, Q, Delpire, E, Hebert, S C, Strange, K. Functional demonstration of Na+-K+-2Cl- cotransporter activity in isolated, polarized choroid plexus cells. Am J Physiol, 275(6 Pt 1), C1565-72, 1998. Partial cloning and
characterization of SLC12a2: the gene encoding the
secretory Na+-K+-2Cl- cotransporter. Randall J, Thorne T and Delpire E. Am J Physiol Cell, 272, C1267-C1277, 1997. Plotkin MD, Snyder EY, Hebert SC and Delpire
E. Expression of the Na-K-2Cl cotransporter is
developmentally regulated in postnatal rat brains. J Neurobiol, 33(6), 781-795, 1997. Plotkin, M D, Kaplan, M R, Peterson, L N, Gullans, S R, Hebert, S C, Delpire, E. Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system. Am J Physiol, 272(1 Pt 1), C173-83, 1997. Plotkin, M D, Snyder, E Y, Hebert, S C, Delpire, E. Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA''s excitatory role in immature brain. J Neurobiol, 33(6), 781-95, 1997. Randall, J, Thorne, T, Delpire, E. Partial cloning and characterization of Slc12a2: the gene encoding the secretory Na+-K+-2Cl- cotransporter. Am J Physiol, 273(4 Pt 1), C1267-77, 1997. Delpire, E, Kaplan, M R, Plotkin, M D, Hebert, S C. The Na-(K)-Cl cotransporter family in the mammalian kidney: molecular identification and function(s). Nephrol Dial Transplant, 11(10), 1967-73, 1996. Kaplan, M R, Mount, D B, Delpire, E. Molecular mechanisms of NaCl cotransport. Annu Rev Physiol, 58, 649-68, 1996. Kaplan, M R, Plotkin, M D, Brown, D, Hebert, S C, Delpire, E. Expression of the mouse Na-K-2Cl cotransporter, mBSC2, in the terminal inner medullary collecting duct, the glomerular and extraglomerular mesangium, and the glomerular afferent arteriole. J Clin Invest, 98(3), 723-30, 1996. PMCID:507482 Klingensmith, M E, Hallonquist, H, McCoy, B P, Cima, R R, Delpire, E, Soybel, D I. Pentagastrin selectively modulates levels of mRNAs encoding apical H/K adenosine triphosphatase and basolateral Na-K-Cl cotransporter in rat gastric fundic mucosa. Surgery, 120(2), 242-6; discussion 246-7, 1996. Raat, N J, Delpire, E, van Os, C H, Bindels, R J. Culturing induced expression of basolateral Na+-K+-2Cl- cotransporter BSC2 in proximal tubule, aortic endothelium, and vascular smooth muscle. Pflugers Arch, 431(3), 458-60, 1996. Soybel, D I, Gullans, S R, Maxwell, F, Delpire, E. Role of basolateral Na(+)-K(+)-Cl- cotransport in HCl secretion by amphibian gastric mucosa. Am J Physiol, 269(1 Pt 1), C242-9, 1995. Delpire, E, Gullans, S R. Cell volume and K+ transport during differentiation of mouse erythroleukemia cells. Am J Physiol, 266(2 Pt 1), C515-23, 1994. Delpire, E, Rauchman, M I, Beier, D R, Hebert, S C, Gullans, S R. Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. J Biol Chem, 269(41), 25677-83, 1994. Wasserman, J C, Delpire, E, Tonidandel, W, Kojima, R, Gullans, S R. Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter. Am J Physiol, 267(4 Pt 2), F688-94, 1994. Rauchman, M I, Nigam, S K, Delpire, E, Gullans, S R. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol, 265(3 Pt 2), F416-24, 1993. Delpire, E, Lauf, P K. Kinetics of DIDS inhibition of swelling-activated K-Cl cotransport in low K sheep erythrocytes. J Membr Biol, 126(1), 89-96, 1992. Lauf, P K, Bauer, J, Adragna, N C, Fujise, H, Zade-Oppen, A M, Ryu, K H, Delpire, E. Erythrocyte K-Cl cotransport: properties and regulation. Am J Physiol, 263(5 Pt 1), C917-32, 1992. Delpire, E, Cornet, M, Gilles, R. Volume regulation in rat pheochromocytoma cultured cells submitted to hypoosmotic conditions. Arch Int Physiol Biochim Biophys, 99(1), 71-6, 1991. Delpire, E, Lauf, P K. Kinetics of Cl-dependent K fluxes in hyposmotically swollen low K sheep erythrocytes. J Gen Physiol, 97(2), 173-93, 1991. PMCID:2216477 Delpire, E, Lauf, P K. Magnesium and ATP dependence of K-Cl co-transport in low K+ sheep red blood cells. J Physiol, 441, 219-31, 1991. PMCID:1180194 Delpire, E, Lauf, P K. Trans effects of cellular K and Cl on ouabain-resistant Rb(K) influx in low K sheep red blood cells: further evidence for asymmetry of K-Cl cotransport [corrected. Pflugers Arch, 419(5), 540-2, 1991. Buche, A, Ouassaidi, A, Hacha, R, Delpire, E, Gilles, R, Houssier, C. Glycine and other amino compounds prevent chromatin precipitation at physiological ionic strength. FEBS Lett, 247(2), 367-70, 1989. Cornet, M, Delpire, E, Gilles, R. Relations between cell volume control, microfilaments and microtubules networks in T2 and PC12 cultured cells. J Physiol (Paris), 83(1), 43-9, 1988. Delpire, E, Duchêne, C, Cornet, M, Gilles, R. Amiloride: an inhibitor of regulatory volume decrease in rat pheochromocytoma cultured cells. Pflugers Arch, 411(2), 223-5, 1988. Cornet, M, Delpire, E, Gilles, R. Study of microfilaments network during volume regulation process of cultured PC 12 cells. Pflugers Arch, 410(1-2), 223-5, 1987. Delpire, E, Duchêne, C, Goessens, G, Gilles, R. Effects of osmotic shocks on the ultrastructure of different tissues and cell types. Exp Cell Res, 160(1), 106-16, 1985. |
